نتایج جستجو برای: Glutamatergic transmission

تعداد نتایج: 251772  

Objective(s): The present study aims to study the alteration of glutamatergic transmission in the dorsal horn neurons and the effect of gabapentin on oxaliplatin-induced neuropathic pain in rats. Materials and Methods: Oxaliplatin (5 mg/kg) or saline was administered to adult male Sprague-Dawley rats.  Gabapentin (60 mg/kg, IP) or vehicle was injected daily. Mechanical allodynia was assessed us...

Journal: :iranian journal of basic medical sciences 0
teng ruyang department of anesthesiology, the affiliated hospital of qingdao university, qingdao 266100, china zhao yang department of anesthesiology, the affiliated hospital of qingdao university, qingdao 266100, china feng wei department of anesthesiology, the affiliated hospital of qingdao university, qingdao 266100, china

objective(s): the present study aims to study the alteration of glutamatergic transmission in the dorsal horn neurons and the effect of gabapentin on oxaliplatin-induced neuropathic pain in rats. materials and methods: oxaliplatin (5 mg/kg) or saline was administered to adult male sprague-dawley rats.  gabapentin (60 mg/kg, ip) or vehicle was injected daily. mechanical allodynia was assessed us...

Journal: :basic and clinical neuroscience 0
fatemeh khakpai institute for cognitive science studies (icss), tehran, iran. mohammad nasehi department of biology, faculty of basic sciences, islamic azad university, garmsar branch, semnan, iran. ali haeri-rohani institute for cognitive science studies (icss), tehran, iran. akram eidi institute for cognitive science studies (icss), tehran, iran. mohammad reza zarrindast institute for cognitive science studies (icss), tehran, iran.

the cholinergic and gabaergic .bers of the medial septal/diagonal band of broca (ms/db) area project to the hippocampus and constitute the septo-hippocampal pathway, which has been proven to play a role in learning and memory. in addition, the hippocampus has bidirectional connections with the septum so that to self-regulate of cholinergic input. the activity of septal and hippocampal neurons i...

Journal: :Current Opinion in Psychiatry 2012

Akram Eidi, Ali Haeri-Rohani, Fatemeh Khakpai, Mohammad Nasehi, Mohammad Reza Zarrindast,

The Cholinergic and GABAergic .bers of the medial septal/diagonal band of Broca (MS/DB) area project to the hippocampus and constitute the septo-hippocampal pathway, which has been proven to play a role in learning and memory. In addition, the hippocampus has bidirectional connections with the septum so that to self-regulate of cholinergic input. The activity of septal and hippocampal neuron...

Journal: :Frontiers in Molecular Neuroscience 2019

Journal: :Journal of neurophysiology 2010
Maxim Kozhemyakin Karthik Rajasekaran Jaideep Kapur

Central cholinergic overstimulation results in prolonged seizures of status epilepticus in humans and experimental animals. Cellular mechanisms of underlying seizures caused by cholinergic stimulation remain uncertain, but enhanced glutamatergic transmission is a potential mechanism. Paraoxon, an organophosphate cholinesterase inhibitor, enhanced glutamatergic transmission on hippocampal granul...

2008
Justin T. Gass

The past two decades have witnessed a dramatic accumulation of evidence indicating that the excitatory amino acid glutamate plays an important role in drug addiction and alcoholism. The purpose of this review is to summarize findings on glutamatergic substrates of addiction, surveying data from both human and animal studies. The effects of various drugs of abuse on glutamatergic neurotransmissi...

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